OUR PLATFORM STRATEGY

One Platform.Multiple Blueprints.

Providing the foundational science and scaleable potential for future development.

Our Blueprint

Repair and regeneration requires more than a single component. It requires a foundational structure that more closely reflects the complexity of the body’s own extracellular matrix (ECM).

Our patented CXU ECM is designed to serve as that foundation.  Composed of multiple ECM proteins, structural elements and sugars, it is engineered to more closely mimic human tissue ECM than collagen alone.

Following tissue loss or damage, the body’s structural foundation can be diminished or disrupted. CXU is designed as a biomimetic ECM intended to support cell migration, vascularization, integration and the conditions tissue repair and regeneration depend on.

The Tissue

Regeneration Trilogy

Tissue regeneration depends on three essential elements working together in the body: cells, signals, and the ECM scaffold.  Cells build new tissue, signals guide cellular activity and the ECM scaffold provides the structural framework that supports repair and regeneration.

Our body’s scaffold can be compromised in different ways.  It can be destroyed by injury, diminished over time, or depleted by weight loss. When this happens, the structural framework that supports tissue regeneration begins to break down.

CXU is being developed as a collagen-based ECM scaffold intended to help restore the missing structure and support a more restorative environment for the tissue.

Regeneration requires the coordinated presence of:
Repopulate

CXU™ scaffold is designed to provide a structural environment that may support host cell integration and remodeling, to enable multi-cell migration and proliferation within the ECM scaffold.

Remodel

CXU™ scaffold is designed to provide a structural environment that may support host cell integration and remodeling, to enable multi-cell migration and proliferation within the ECM scaffold.

Regenerate

CXU™ scaffold is designed to provide a structural environment that may support host cell integration and remodeling, to enable multi-cell migration and proliferation within the ECM scaffold.

Regeneration requires the coordinated presence of:
Repopulate

CXU™ scaffold is designed to provide a structural environment that may support host cell integration and remodeling, to enable multi-cell migration and proliferation within the ECM scaffold.

Remodel

CXU™ scaffold is designed to provide a structural environment that may support host cell integration and remodeling, to enable multi-cell migration and proliferation within the ECM scaffold.

Regenerate

CXU™ scaffold is designed to provide a structural environment that may support host cell integration and remodeling, to enable multi-cell migration and proliferation within the ECM scaffold.

LEARN MORE ABOUT THE MOA
*Design intent; preclinical data, not predictive of clinical outcomes.
**Observations from preclinical studies. Clinical significance not yet established.

How CXU Works

A deeper dive into the science of Conexeu

How CXU Works

Flow

Starts as a flowable liquid

At room temperature, CXU flows to fill voids  where tissue has been lost, maintaining continuous contact for seamless adaptation in the body’s tissue spaces.1,2,3,4,5

WATCH NOW
Repopulate

CXU™ scaffold is designed to provide a structural environment that may support host cell integration and remodeling, to enable multi-cell migration and proliferation within the ECM scaffold.

Remodel

CXU™ scaffold is designed to provide a structural environment that may support host cell integration and remodeling, to enable multi-cell migration and proliferation within the ECM scaffold.

Regenerate

CXU™ scaffold is designed to provide a structural environment that may support host cell integration and remodeling, to enable multi-cell migration and proliferation within the ECM scaffold.

*Design intent; preclinical data, not predictive of clinical outcomes.
**Observations from preclinical studies. Clinical significance not yet established.

How CXU Works

Set

Set as a gel

After ~10 minutes at 37°C, CXU transforms into a gel that provides volume and creates a stable interface: 1,2,3,4,6

WATCH NOW
Repopulate

CXU™ scaffold is designed to provide a structural environment that may support host cell integration and remodeling, to enable multi-cell migration and proliferation within the ECM scaffold.

Remodel

CXU™ scaffold is designed to provide a structural environment that may support host cell integration and remodeling, to enable multi-cell migration and proliferation within the ECM scaffold.

Regenerate

CXU™ scaffold is designed to provide a structural environment that may support host cell integration and remodeling, to enable multi-cell migration and proliferation within the ECM scaffold.

*Design intent; preclinical data, not predictive of clinical outcomes.
**Observations from preclinical studies. Clinical significance not yet established.

How CXU Works

Regenerate*

Starts as a flowable liquid

At room temperature, CXU flows to fill voids  where tissue has been lost, maintaining continuous contact for seamless adaptation in the body’s tissue spaces.1,2,3,4,5

WATCH NOW
Repopulate

CXU™ scaffold is designed to provide a structural environment that may support host cell integration and remodeling, to enable multi-cell migration and proliferation within the ECM scaffold.

Remodel

CXU™ scaffold is designed to provide a structural environment that may support host cell integration and remodeling, to enable multi-cell migration and proliferation within the ECM scaffold.

Regenerate

CXU™ scaffold is designed to provide a structural environment that may support host cell integration and remodeling, to enable multi-cell migration and proliferation within the ECM scaffold.

*Design intent; preclinical data, not predictive of clinical outcomes.
**Observations from preclinical studies. Clinical significance not yet established.

Deeply Rooted in Science and Development.

Conexeu is not simply repairing tissue. We are building a new blueprint for regeneration, one that is disciplined, intentional and grounded in more than a decade of research.

10 Years of Development

Developed over 10 years at the University of British Columbia, recipient of institutional and think tank awards

11 Peer-Reviewed Publications

Acta Biomaterialia, Advances in Wound Care, Biomedical Materials, Canadian Journal of Diabetes, Experimental Dermatology, Gels, Journal of Burn Care, Tissue Engineering, Transplantation

1 Patent, 5 Jurisdictions (Canada Pending)*

*All cited studies are preclinical. Findings have not been validated in human clinical trials and are not predictive of clinical outcomes.

CXU Applications

One platform, one formula, one device for broad potential use across a range of human and animal applications.

Across these applications, Conexeu is at the forefront of tissue engineering.  

News and Media

Stay in the know about Conexeu, CXU and the future of regenerative science.
IMPORTANT NOTICES: CXU™ is a medical device candidate in preclinical development. It has not been submitted to or reviewed by the U.S. Food and Drug Administration. Safety and effectiveness have not been established. See Forward-Looking Cautionary Statement.Terms such as 'next-generation,' 'advanced,' 'innovative,' and 'bioregenerative' reflect the Company's assessment of its technology relative to existing approaches and are not intended as representations of regulatory status, clinical performance, or guaranteed commercial outcomes. CXU™ is an investigational medical device candidate. Safety and effectiveness have not been established. See Forward-Looking Cautionary Statement.
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