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Architects of 3D Bioprinting

Designed to help build tissue with greater precision.
In 3D bioprinting applications, the challenge is not only creating shape, it is creating the environment for tissue to regenerate. When tissue has been lost to trauma, disease or surgical resection, the body is left with a structural void it cannot rebuild at scale on its own. Many existing materials only focus on coverage, and not the structural integration that allows for and supports regenerative tissue formation.
This is the unmet need CXU™ is poised to address.

Overview

Engineered to mimic the body's natural extracellular matrix, CXU for 3D bioprinting is being developed to print tissue structures that conform to complex anatomy. Designed to support cell infiltration and vascular ingrowth for more organized healing. A stable, patient-matched scaffold designed to fit target geometry across multiple soft tissue applications.

CAUTION: CXU™ is a medical device candidate in preclinical development and is not cleared or approved for marketing in the United States or any other jurisdiction.

How CXU Works

How it works

The CXU formula is designed to print a permissive and adaptive ECM to help build tissue with greater precision and biological intent.12

Flow
  • Low-viscosity liquid state enables delivery through standard bioprinter nozzles without clogging or flow restriction
  • High potential for print resolution and infill density across complex anatomical geometries
  • Maintains structural fidelity from deposition through thermal gelation, layer integrity preserved without collapse or spread
Integrate3,5
  • Thermally induced self-crosslinking at at 37°C, no chemical initiators, no UV curing, no secondary agents required
  • Forms a stable, ECM scaffold within approximately 10 minutes, dimensionally stable, patient-matched construct
Regenerate6
  • Designed to support cell migration, tissue in-growth, and vasculogenisis  and vasulogenisis within the printed construct
  • Intended to support organized remodeling of the printed ECM scaffold into functional tissue architecture.
  • Positions the construct for tissue integration, designed to be recognized and remodeled by host tissue rather than encapsulated or rejected
CAUTION: CXU™ is a medical device candidate in preclinical development and is not cleared or approved for marketing in the United States or any other jurisdiction.

Key Features

When the tissue must be rebuilt with structural precision, CXU is designed to provide these benefits.*,1, 3, 9

Custom Geometry

Printed tissue structures designed for patient-specific anatomical fit across multiple soft tissue applications.

Conformability

An in-situ-scaffold, integrated for continuous wound-bed contact may support vascular infiltration across the entire structures interface.

Biomimetic Support

Designed to support cell migration, adipogenesis and vasculogenesis and organized remodeling within the printed construct.

*Design intent based on preclinical evidence. These findings were generated in controlled laboratory settings and animal models. Animal physiology differs from human physiology and these findings may not be predictive of clinical performance or safety in humans. Clinical significance not yet established.

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IMPORTANT NOTICES: CXU™ is a medical device candidate in preclinical development. It has not been submitted to or reviewed by the U.S. Food and Drug Administration. Safety and effectiveness have not been established. See Forward-Looking Cautionary Statement.Terms such as 'next-generation,' 'advanced,' 'innovative,' and 'bioregenerative' reflect the Company's assessment of its technology relative to existing approaches and are not intended as representations of regulatory status, clinical performance, or guaranteed commercial outcomes. CXU™ is an investigational medical device candidate. Safety and effectiveness have not been established. See Forward-Looking Cautionary Statement.
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