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References

Architecting Bioregeneration™
  1. Hartwell R., Leung V., Chavez-Munoz C., et al. "A novel hydrogel-collagen composite improves functionality of an injectable extracellular matrix." Acta Biomaterialia (2011) 7; 3060–3069. DOI: https://doi.org/10.1016/j.actbio.2011.04.024‍
  2. Hosseini-Tabatabaei A., Jalili R., Hartwell R., et al. "Embedding islet in a liquid scaffold increases islet viability and function." Canadian Journal of Diabetes (2013) 37; 27–35. DOI: https://doi.org/10.1016/j.jcjd.2012.10.011‍
  3. Hartwell R., Poormasjedi-Meibod MS., Chavez-Munoz C., et al. "An in-situ forming skin substitute improves healing outcome in a hypertrophic scar model." Tissue Engineering Part A (2015) 21(5); 1085–1094. DOI: https://doi.org/10.1089/ten.tea.2014.0271‍
  4. Hosseini-Tabatabaei A., Jalili R., Khosravi-Maharlooei M., et al. "Immunoprotection and functional improvement of allogeneic islets in diabetic mice, using stable indoleamine 2,3-dioxygenase producing scaffold." Transplantation (2015) 99; 1342–1348. DOI: https://doi.org/10.1097/TP.0000000000000661‍
  5. Hartwell R., Chan B., Elliott K., et al. "Polyvinyl alcohol-graft-polyethylene glycol hydrogels improve utility and biofunctionality of injectable collagen biomaterials." Biomedical Materials (2016) 11; 035013. DOI: https://doi.org/10.1088/1748-6041/11/3/035013‍
  6. Forbes D., Russ B., Kilani RT., et al. "Liquid dermal scaffold with adipose-derived stem cells improves tissue quality in a murine model of impaired wound healing." Journal of Burn Care & Research (2019) 40(5); 550–557. DOI: https://doi.org/10.1093/jbcr/irz099‍
  7. Pourghadiri A., Alnojeidi H., Jalili R., et al. "In situ forming nutritional and temperature sensitive scaffold improves the aesthetic outcome of meshed split-thickness skin grafts in a porcine model." Advances in Wound Care (2021) 10(3); 113–122. DOI: https://doi.org/10.1089/wound.2019.1108‍
  8. Pangli H., Vatanpour S., Hortamani S., et al. "Incorporation of silver nanoparticles in hydrogel matrices for controlling wound infection." Journal of Burn Care & Research (2021) 42(4); 785–793. DOI: https://doi.org/10.1093/jbcr/iraa205‍
  9. Pakyari M., Jalili R., Kilani R.T., et al. "Studying the in vivo application of a liquid dermal scaffold in promoting wound healing." Experimental Dermatology (2021) 31; 715–724. DOI: https://doi.org/10.1111/exd.14504‍
  10. Alnojeidi H., Kilani RT., Ghahary A. "Evaluating the biocompatibility of an injectable wound matrix in a murine model." Gels (2022) 8; 49. DOI: https://doi.org/10.3390/gels8010049‍
  11. Amiri N., Ghaffari S., Hassanpour I., et al. "Antibacterial thermosensitive silver-hydrogel nanocomposite improves wound healing." Gels (2023) 9; 542. DOI: https://doi.org/10.3390/gels9070542‍
  12. Data on File. Conexeu. 2026. Preclinical findings; not peer-reviewed. Clinical significance not yet established.
IMPORTANT NOTICES: CXU™ is a medical device candidate in preclinical development. It has not been submitted to or reviewed by the U.S. Food and Drug Administration. Safety and effectiveness have not been established. See Forward-Looking Cautionary Statement.Terms such as 'next-generation,' 'advanced,' 'innovative,' and 'bioregenerative' reflect the Company's assessment of its technology relative to existing approaches and are not intended as representations of regulatory status, clinical performance, or guaranteed commercial outcomes. CXU™ is an investigational medical device candidate. Safety and effectiveness have not been established. See Forward-Looking Cautionary Statement.

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